美国气候学家杰克（丹尼斯?奎德 Dennis Quaid 饰）认为，温室效应正在引发地球的大灾难，北极冰川的融化，会让地球回到冰河世纪那样的劫难。他的提醒并没有引起美国当局的重视，一切都已经太晚：飓风、冰雹、洪水、冰山融化、极度严寒，一系列的地球巨变引发了一场不可挽救的灾难。美国政府组织北纬30度的民众转移到赤道周围，场面一片混乱。更糟糕的是，杰克的儿子，正困在曼哈顿的图书馆里，靠烧书生火来维持体温。大家怎样才能逃过这场灭顶的灾祸？冰天雪地的地球何时才能回暖？
Back in the 80s, five friends cause raucous in their schooldays. Twenty years on and they've got jobs they don't want and wives who don't want them. The leader of the gang, Frankie, is now dying in Yorkshire. The others find out and they get together for one last sad, mad, bad road trip to Dewsbury, before it's all too late. Mix in a dollop of The Inbetweeners' intellectual wit, add a pinch of bromancing from The World's End, and then stir in a few ladles of The Hangover's vomit and you've got Destination: Dewsbury, destined to be one of 2018's funniest releases.